ABSTRACT
Obesity, a state of hyperleptinemia and leptin resistance, may play a role in the aeitiopathogenesis of type 2 diabetes mellitus. Leptin hormone which was originally recognized for its role as a satiety factor has now been implicated in a wide variety of multisystem biological functions, including the regulation of glucose homeostasis. However, there is paucity of information regarding leptin and its effect on the West African population. This study was therefore aimed at studying the relationship between leptin, obesity and insulin levels in type 2 diabetes mellitus. One hundred and eighty- three diabetics (183) and 96 control non-diabetics were studied. Pulse, blood pressure and anthropometric parameters of all the respondents were measured. Fasting blood sugar (FBS) was analyzed using the glucose oxidase method and lipid profile was determined using enzymatic method. Serum leptin and serum insulin were also analysed using enzyme linked immunoassay (ELISA) method. Homeostasis Model Assessment was used to determine insulin resistance. Type 2 diabetes mellitus patients and non- diabetic controls that were normotensive with no disease complications or associated chronic illness were used for the study. The mean serum leptin levels for the diabetics and non diabetics was observed to be 4.57 ± 0.17 ng/ml and 4.70 ± 0.25ng/ml respectively (p > 0.05) and the mean insulin level for the diabetic and non diabetic groups are 4.70 ± 0.25 μU/mL and 4.49 ± 0.01
μU/mL respectively (p < 0.05). A positive correlation was observed between leptin and body mass index (BMI) in both type 2 diabetic patients (r = 0.36, p < 0.05) and non-diabetics (r = 0.48, p < 0.05). A positive correlation was also found between leptin and waist circumference (WC) in both type 2 diabetic patients (r = 0.32, p < 0.05) and non-diabetics (r = 0.39, p < 0.05). Hip circumference (HC) also correlated positively with leptin in both the diabetics (r = 0.33, p < 0.05) and non-diabetics. The study also found a positive correlation between leptin and FBS in the non-diabetic group (r = 0.21, p < 0.05) but a negative correlation in the diabetic group(r = – 0.18, p < 0.05). A correlation was also found between leptin and HOMA-IR in both the diabetic (r = – 0.018, p < 0.05) and non-diabetics (r = 0.20, p < 0.05). However there was no significant relationship between leptin and insulin in both type 2 diabetic patients (r = 0.11, p > 0.05) and non-diabetics (r = – 0.06, p < 0.05). Age, BMI and WC emerged as the independent predictors of leptin in the diabetic group while BMI, WC and HC emerged as independent predictors of leptin in the non-diabetics.
Terms of Use: This is an academic paper. Students should NOT copy our materials word to word, as we DO NOT encourage Plagiarism. Only use as a guide in developing your original research work. Thanks.
Disclaimer: All undertaking works, records, and reports posted on this website, eprojectguide.com are the property/copyright of their individual proprietors. They are for research reference/direction purposes and the works are publicly supported. Do not present another person’s work as your own to maintain a strategic distance from counterfeiting its results. Use it as a guide and not duplicate the work in exactly the same words (verbatim). eprojectguide.com is a vault of exploration works simply like academia.edu, researchgate.net, scribd.com, docsity.com, course hero, and numerous different stages where clients transfer works. The paid membership on eprojectguide.com is a method by which the site is kept up to help Open Education. In the event that you see your work posted here, and you need it to be eliminated/credited, it would be ideal if you call us on +2348064699975 or send us a mail along with the web address linked to the work, to eprojectguide@gmail.com. We will answer to and honor each solicitation. Kindly note notification it might take up to 24 – 48 hours to handle your solicitation.