ABSTRACT
Urinary tract infection (UTI) is a common infection of human being and if untreated could lead to serious complications. This study was conducted to investigate the antibiotic susceptibility pattern of uropathogens from patients in two hospitals in Birnin kudu, Jigawa State, Nigeria. In this study, the antibiotic resistance profile and the plasmid profile of some multi-antibiotic resistant bacteria isolated from urine samples of patients from Birnin kudu community in North-west, Nigeria were analysed. Rapid diagnostic kit systems were used in identification of the isolated bacteria and agar disc diffusion technique was used for the determination of antibiotic susceptibility profiles of the isolated bacteria. Presence of β- lactamase was determined using standardized β-lactamase identification sticks while acridine orange was used for curing of multidrug resistant isolates. The cultures of some multi- antibiotic resistant isolates irreversibly lost their antibiotic resistance with acridine orange treatment, which suggests that the resistant genes could be harboured in the plasmids. The result showed that 94.3% of the isolates were resistant to Ampicillin, Amoxycillin-clavulanic acid (71.5%), Ceftriaxone (35.4%), Cefuroxime (57.3), Cotrimoxazole (73.1%), Nitrofurantoin (24.6%), Chloranphenicol (36.9), Doxycycline (58.0%), Ciprofloxacin (60.0%) and Gentamicin (61.2%). Out of 36 isolates tested for presence of β- lactamse, 66.1% possessed β- lactamases. Plasmid profile studies revealed the presence of plasmid of size range 5184.8kb – 5673.9bp.
CHAPTER ONE
1.1 BACKGROUND OF THE STUDY
Urinary Tract Infection (UTI) is an infection that affects part of the urinary tract. When it affects the lower urinary tract, it is known as a simple cystitis (a bladder infection) but when it affects the upper urinary tract, it is known as pyelonephritis (a kidney infection). Lower urinary tract infection is characterized by burning sensation during urination with either frequent urination or urge to urinate or both and is often accompanied with significant pain (Nicolle, 2008). These symptoms may vary from mild to severe (Lane and Takhar, 2011) and in healthy women, can last an average of six days (Colgan and Willliams, 2011). Upper urinary tract infection is characterized by flank pain, fever, or nausea and vomiting in addition to classic symptoms of a lower urinary tract infection (Lane and Takhar, 2011). Rarely, the urine may appear bloody or contain visible pus. In children, the symptoms may be a fever. Infants may feed poorly, vomit, sleep more or show signs of jaundice. In older children, new onset urinary incontinence may occur.
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